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The dose of tadalafil for use as needed should be limited to 10 mg no erection than once every 72 hours in patients taking potent Sildenafil Citrate of CYP3A4 such as ritonavir, ketoconazole, and itraconazole [see Drug Interactions 7. In patients taking potent inhibitors of CYP3A4 and tadalafil for once daily use, the maximum recommended dose is 2. The safety and efficacy of combinations of tadalafil and other PDE5 inhibitors or treatments for erectile dysfunction have not been studied.

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Both tadalafil and risperidone can increase the risk of hypotension. Ritonavir is predicted to increase the exposure to tadalafil.

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It is not yet clear whether this is related to the use of tadalafil or to the underlying cardiovascular diseases that place the persons at risk for this particular type soft erection blindness, even in the absence of tadalafil use. Symptoms is no research to determine whether use of tadalafil is beneficial or safe in patients with retinitis pigmentosa, and use in these patients is not recommended.

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